Boris Johnson is to attempt to reassure voters who are angry and alienated by Brexit that the UK's split from the EU is a cause for "hope not fear, BBC reports.
The foreign secretary will use a speech to try to build bridges with those who voted to remain in the EU, saying their belief in European solidarity is based on "noble sentiments".
"It is not good enough to say 'you lost, get over it'," he will say.
But he will also insist those who want to stop Brexit cannot prevail.
In the speech in London, he will say that that holding another referendum on the UK's membership of the EU would be a "disastrous mistake that would lead to permanent and ineradicable feelings of betrayal".
His is the first in a series of speeches by Theresa May and her ministers on the "road to Brexit".
The prime minister is expected to address the UK's future relations with the EU in a speech in Munich on Saturday, the day after she holds talks with German Chancellor Angela Merkel in Berlin